Type of Drug

Type of Herb

Possible Effects if Combined

Anti-allergy drugs such as diphenhydramine (Benedryl), hydroxyzine (Vistaril) and astemizole (Hismanal)

Sedative herbs such as passionflower, skullcap, kava kava and valerian

Drowsiness caused by antihistamine drugs may be increased

Diuretics such as furosimide (Lasix and indapamide (Lozol)

Diuretic herbs such as buchu, cornsilk, dandelion, uva-ursi and yarrow

Diuretic effects may be much stronger with a risk of abnormally low potassium levels

Antidepressants such as fluoxetine (Prozac), amitriptyline (Elavil) and imipramine (Tofranil)

Sedative herbs such as passionflower, skullcap, kava kava and valerian

The drug’s sedative effect may be increased

Cardiac glycosides such as digitalis medications like digitoxin (Crystodigin) and digoxin (Lanoxin)

Herbs affecting the cardiovascular system, such as coltsfoot, goldenseal, hawthorn and motherwort

Drug’s effect may be increased

Blood pressure medications such as nifedipine (Adalat), enalapril (Vasotec) and prazosin (Minizide)

Herbs that raise blood pressure such as licorice

Diuretic herbs and herbs with ingredients that may lower BP such as garlic and hawthorn

Drug’s effect may be lessened

Drug’s effects may be increased or altered

Hypnotic and mild sedatives such as flurazepam (Dalmane), diazepam (Valium) and alprazolam (Xanax)

Sedative herbs such as passionflower, skullcap, kava kava and valerian

Drug’s effects may be increased

Laxative drugs such as psyllium (Cillium), docusate sodium (Colace) and polycarbophil (Fibercon)

Laxative herbs such as aloes, cascara sagrada, plantain, rhubarb, senna and yellow dock

Drug’s effects may be increased