Class: Sympathomimetic, bronchodilator

Description

Terbutaline is selective for beta2-adrenergic receptors, resulting in relaxation of smooth muscles of the bronchial tree and peripheral vasculature. lt is effective in producing immediate bronchodilation with minimal cardiac effects.

Onset & Duration

Onset: (SQ) 15-30 min

(MDI) 5-30 min

Duration: (SQ) 1 5-4 hr

(MDI) 3-6 hr

Indications

Bronchial asthma

Reversible bronchospasm associated with exercise, chronic bronchitis, and emphysema

Contraindications

Hypersensitivity Tachydysrhythmias

Digitalis-induced tachycardia

Adverse Reactions

Usually transient and dose related

Restlessness, apprehension Palpitations

Tachycardia Chest pain

Coughing Bronchospasm

Nausea Facial flushing

Drug Interactions

Other sympathomimetics may exacerbate adverse cardic-vascular effects.

MAOIs may potentiate tachydysrhythmias.

Beta blockers may antagonize terbutaline.

How Supplied

Tablet: 2 5, 5 mg

MDI: 200 mcg/metered spray

Parenteral: 1 mg/ml ampule

Dosage and Administration

Adult: 0.25 mg SQ; may repeat in 1 5-30 min (maximum dose 0 5 mg/4 hr)

400 mcg (two inhalations by MDI) q 4-6 hr; allow 1-2 min between inhalations

Pediatric: Not recommended for children under 12

0.01 mg/kg/dose SQ q 15-20 min prn (maximum 0.25 mg dose)

0 03-0 G5 mg/kg in 1.25 ml saline for aerosolization q 4 hr

Special Considerations

Pregnancy safety: Category B.

Carefully monitor vital signs.

Use with caution in patients with cardiovascular disease or hypertension.